Ligand id: 9330

Name: CDP840

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 31.35
Molecular weight 373.2
XLogP 8.29
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Cyclic-AMP-specific isoenzyme phosphodiesterase 4 (PDE4) is the predominant PDE found in proinflammatory cells. Inhibition of the PDE4 in these cells effectively elevates the intracellular cAMP levels, which in turn inhibits release of inflammatory mediators. This action dampens the inflammatory response, which is expected to translate to clinical benefit in inflammatory diseases such as asthma and COPD.