BI605906

Ligand id: 9357

Name: BI605906

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 156
Molecular weight 432.11
XLogP 1.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In vivo data for BI605906 (compound 115) in a rat collagen-induced arthritis model is disclosed in US20070293533 [2].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
inhibitor of nuclear factor kappa B kinase subunit beta Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.6x10-8 M) [2]