CCR2-RA-[R]

Ligand id: 9431

Name: CCR2-RA-[R]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 57.61
Molecular weight 351.1
XLogP 5.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CCR2-RA-[R] exhibits favourable activity, selectivity and in vivo profile [1]. In preclinical murine models of inflammation it is active in delayed-type hypersensitivity and antigen-induced lung inflammation.
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
CCR2 Hs Allosteric modulator Antagonist >5.3 pIC50 - 1,4
pIC50 >5.3 (IC50 <5x10-6 M) [1,4]
Description: Antagonism of 125I-MCP-1 binding to THP-1 cells