Ligand id: 9431

Name: CCR2-RA-[R]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 57.61
Molecular weight 351.1
XLogP 5.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CCR2-RA-[R] exhibits favourable activity, selectivity and in vivo profile [1]. In preclinical murine models of inflammation it is active in delayed-type hypersensitivity and antigen-induced lung inflammation.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CCR2 Allosteric modulator Antagonist >5.3 pIC50 - 1,4
pIC50 >5.3 (IC50 <5x10-6 M) [1,4]
Description: Antagonism of 125I-MCP-1 binding to THP-1 cells