Ligand id: 9431

Name: CCR2-RA-[R]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 57.61
Molecular weight 351.1
XLogP 5.13
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
CCR2 and its ligands are implicated in numerous inflammatory and neurodegenerative diseases [2]. Drug discovery efforts are targeting the CCR2-chemokine axis for conditions including atherosclerosis, multiple sclerosis, asthma, neuropathic pain, diabetic nephropathy and cancer.