17β-estradiol

Ligand id: 1013

Name: 17β-estradiol

Abbreviated name: E2

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 40.46
Molecular weight 272.18
XLogP 4.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK
No information available.
Summary of Clinical Use
Estradiol is used to treat unwanted post-menopausal symptoms associated with atrophy of the vagina and/or lower urinary tract.
Drug formulations may contain estradiol valerate.
Mechanism Of Action and Pharmacodynamic Effects
Estradiol bound to its receptor acst as a transcription factor, regulating target gene transcription and protein synthesis.