rosiglitazone

Ligand id: 1056

Name: rosiglitazone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 96.83
Molecular weight 357.11
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
An anti-diabetic drug. All EMA approvals for this drug have been withdrawn or suspended, due to concerns over associations with increased risks of heart attacks and death [1].
Mechanism Of Action and Pharmacodynamic Effects
Highly selective agonist at peroxisome proliferator activated receptors in tissues targeted by insulin such as adipose tissue, skeletal muscle and liver. Activation of these receptors improves control of glucose production, transport and utilisation through regulation of the transcription of insulin-responsive genes. This has the effect enhancing tissue sensitivity to insulin.
External links