Synonyms: compound 9 [PMID: 36044257] | GSK'254 | GSK-3640254 | GSK3640254
Compound class:
Synthetic organic
Comment: Fipravirimat (GSK3640254) is an investigational HIV-1 maturation inhibitor (MI) [1]. MIs disrupt the processing of the HIV Gag polyprotein, and this action interferes with the formation of mature, infectious virus particles. Fipravirimat retains activity against HIV-1 with known resistance mutations.
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Clinical Trials | |||||
Clinical Trial ID | Title | Type | Source | Comment | References |
NCT04900038 | A Clinical Trial of GSK3640254 + Dolutegravir (DTG) in Human Immunodeficiency Virus-1 Infected Treatment-naive Adults | Phase 2 Interventional | ViiV Healthcare | ||
NCT04493216 | A Dose-Range Finding Clinical Trial Study in Human Immunodeficiency Virus (HIV-1) Infected Treatment-Naive Adults | Phase 2 Interventional | ViiV Healthcare | ||
NCT03784079 | A Proof of Concept Study of GSK3640254 in Human Immunodeficiency Virus-1 (HIV-1) Infected Treatment-naive Adults | Phase 2 Interventional | ViiV Healthcare | In this study, GSK3640254 was administered as a monotherapy. Results established the dose-antiviral response relationship for GSK3640254 and supported dose selection for phase IIb study NCT04493216. | 2 |