Synonyms: compound 9 [PMID: 36044257] | GSK'254 | GSK-3640254 | GSK3640254
Compound class:
Synthetic organic
Comment: Fipravirimat (GSK3640254) is an investigational HIV-1 maturation inhibitor (MI) [1]. MIs disrupt the processing of the HIV Gag polyprotein, and this action interferes with the formation of mature, infectious virus particles. Fipravirimat retains activity against HIV-1 with known resistance mutations.
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References |
1. Regueiro-Ren A, Sit SY, Chen Y, Chen J, Swidorski JJ, Liu Z, Venables BL, Sin N, Hartz RA, Protack T et al.. (2022)
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation. J Med Chem, 65 (18): 11927-11948. [PMID:36044257] |
2. Spinner CD, Felizarta F, Rizzardini G, Philibert P, Mitha E, Domingo P, Stephan CJ, DeGrosky M, Bainbridge V, Zhan J et al.. (2022)
Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254. Clin Infect Dis, 75 (5): 786-794. [PMID:34996113] |