rifasutenizol   Click here for help

GtoPdb Ligand ID: 12959

Synonyms: TNP-2198
Compound class: Synthetic organic
Comment: Rifasutenizol (formerly TNP-2198) is a rifamycin-nitroimidazole conjugate antibacterial compound [1]. Note that there is some ambiguity in the literature and online chemistry resources as to the precise stereochemistry of this ligand. We have drawn the structure as depicted in its INN record.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 17
Hydrogen bond donors 5
Rotatable bonds 7
Topological polar surface area 264.29
Molecular weight 944.04
XLogP 3.02
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C[C@H]1/C=C/C=C(/C)\C(=O)NC2=C3C(=NC4(CCN(CC4)CCN5C(=NC=C5[N+](=O)[O-])C)N3)C6=C7C(=C(C)C(=C6C2=O)O)O[C@@](C)(C7=O)O/C=C/[C@@H]([C@@H](C)[C@H]([C@H](C)[C@@H]([C@H](C)[C@H]1O)O)OC(=O)C)OC
Isomeric SMILES O=C1C=2NC(/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]([C@H](\C=C\O[C@]3(OC=4C(=C(C1=C(C=5C2NC6(N5)CCN(CCN7C([N+]([O-])=O)=CN=C7C)CC6)C4C3=O)O)C)C)OC)C)OC(C)=O)C)O)C)O)C)/C)=O
InChI InChI=1S/C48H61N7O13/c1-23-12-11-13-24(2)46(62)50-38-37-36(51-48(52-37)15-17-53(18-16-48)19-20-54-29(7)49-22-32(54)55(63)64)33-34(42(38)60)41(59)28(6)44-35(33)45(61)47(9,68-44)66-21-14-31(65-10)25(3)43(67-30(8)56)27(5)40(58)26(4)39(23)57/h11-14,21-23,25-27,31,39-40,43,52,57-59H,15-20H2,1-10H3,(H,50,62)/b12-11+,21-14+,24-13-/t23-,25+,26+,27+,31-,39-,40+,43+,47-/m0/s1
InChI Key GVNMWVKTEANXFY-AIGATTFSSA-N
No information available.
Summary of Clinical Use Click here for help
Rifasutenizol is being evaluated as a treatment for Helicobacter Pylori infections.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05857163 Efficacy and Safety of Rifasutenizol (TNP 2198) in Participants With H. Pylori Infection Phase 3 Interventional TenNor Therapeutics Inc.
NCT06076681 A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules Phase 1/Phase 2 Interventional TenNor Therapeutics Inc.
NCT06076694 Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants Phase 2 Interventional TenNor Therapeutics Inc.