naltrexone

Ligand id: 1639

Name: naltrexone

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View more information in the IUPHAR Pharmacology Education Project: naltrexone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 70
Molecular weight 341.16
XLogP 0.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used alongside behavioural therapy in the management of opiate addiction in patients who have already undergone detoxification, and alongside behavioural therapy in patients with alcohol dependency.
Mechanism Of Action and Pharmacodynamic Effects
Naltrexone antagonises the activity of the opioid receptors in the brain which play a role in addiction. This is postulated to ameliorate the urge to drink in people accustomed to large amounts of alcohol.
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