naltrexone

Ligand id: 1639

Name: naltrexone

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View more information in the IUPHAR Pharmacology Education Project: naltrexone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 70
Molecular weight 341.16
XLogP 0.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1998))
IUPAC Name
(1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18)-trien-14-one
International Nonproprietary Names
INN number INN
3368 naltrexone
Synonyms
(-)naltrexone | naltrexone HCl | ReVia®
Database Links
CAS Registry No. 16590-41-3 (source: Scifinder)
ChEBI CHEBI:7465
ChEMBL Ligand CHEMBL19019
DrugBank Ligand DB00704
PubChem CID 5360515
Search Google for chemical match using the InChIKey DQCKKXVULJGBQN-XFWGSAIBSA-N
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Search PubMed clinical trials naltrexone
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Search UniChem for chemical match using the InChIKey DQCKKXVULJGBQN-XFWGSAIBSA-N
Search UniChem for chemicals with the same backbone DQCKKXVULJGBQN
Wikipedia Naltrexone
Comments
This is the active isomer of naltrexone. The (+) isomer is inactive at the opioid receptors.