codeine

Ligand id: 1673

Name: codeine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.93
Molecular weight 299.15
XLogP 1.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Codeine is used to treat/manage systemic pain. Addtional uses include as an antidiarrheal agent and as a cough suppressant.
Mechanism Of Action and Pharmacodynamic Effects
Codeine is an agonist of the μ (OPRM1), κ (OPRK1) and δ (OPRD1) opioid receptors and may also cause hyperpolarization and reduced neuronal excitability by acting to close N-type voltage-operated calcium channels (OPRK1 receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OPRM1 and OPRD1 receptor agonist).