Ligand id: 1882

Name: PGE1

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 94.83
Molecular weight 354.24
XLogP 3.31
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
The approved drug alprostadil, which is synthetic PGE1, is mainly used to treat erectile dysfunction. It may also be used to maintain the patency of the ductus arteriosus in neonates with congenital heart defects awaiting corrective surgery.
Mechanism Of Action and Pharmacodynamic Effects
Alprostadil's main actions occur via activation of the prostanoid EP1 and EP2 receptors. For an overview of the mechanism of action of alprostadil, please see the DrugBank link on this ligand's Summary tab.
External links