amoxapine

Ligand id: 201

Name: amoxapine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: amoxapine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 36.86
Molecular weight 313.1
XLogP 4.07
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to relieve symptoms of major depressive disorder, endogenous and psychotic depressions and to treat depression accompanied by anxiety or agitation.
Mechanism Of Action and Pharmacodynamic Effects
Amoxapine acts to reduce norepinephrine (noradrenaline) and serotonin (5-HT) reuptake.