Ligand id: 209

Name: perphenazine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: perphenazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 55.25
Molecular weight 403.15
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Perphenazine is an antipsychotic used to treat schizophrenia. Also used for the management of severe nausea and vomiting in adults.
Mechanism Of Action and Pharmacodynamic Effects
Antipsychotic action arises from antagonism of neuronal dopamine D1/D2 receptors. But also has affinity for 5-HT2A , D3, D4 and histamine H1 receptors. Antagonism of dopamine D2 receptors in the vomiting centre and chemoreceptor trigger zone (CTZ) leads to the antiemetic effect of this drug.
External links