perphenazine

Ligand id: 209

Name: perphenazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 55.25
Molecular weight 403.15
XLogP 3.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
D2 receptor Antagonist Antagonist 8.9 – 9.6 pKi - 1,4
pKi 8.9 – 9.6 (Ki 1.4x10-9 – 2.6x10-10 M) [1,4]
5-HT2A receptor Antagonist Antagonist 8.2 pKi - 1
pKi 8.2 [1]
H1 receptor Antagonist Antagonist 8.1 pKi - 1
pKi 8.1 [1]
5-HT7 receptor Antagonist Inverse agonist 7.2 pKi - 2
pKi 7.2 [2]
5-HT6 receptor Antagonist Inverse agonist 7.1 pKi - 2
pKi 7.1 [2]
5-HT2C receptor Antagonist Antagonist 6.9 pKi - 1
pKi 6.9 [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT6 receptor Antagonist Inverse agonist 7.8 pKi - 3
pKi 7.8 [3]
5-HT7 receptor Antagonist Inverse agonist 7.6 pKi - 3
pKi 7.6 [3]