Ligand id: 213

Name: trazodone

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trazodone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 30.03
Molecular weight 371.15
XLogP 3.22
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects
Primarily acts as an antagonist of the serotonin 5-HT2A and 5-HT2C receptors. May have some inhibitory effect on serotonin reuptake via the serotonin transporter (SERT, SLC6A4).
External links