5-Hydroxytryptamine receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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5-HT receptors [nomenclature as agreed by NC-IUPHAR Subcommittee on 5-HT receptors [56] and subsequently revised [49]] are, with the exception of the ionotropic 5-HT3 class, GPCR receptors where the endogenous agonist is 5-HT. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [12,130]. Most 5-HT receptors (except 5-ht 1e and 5-ht 5a/5b) play specific roles mediating functional responses in different tissues (reviewed by [104,124].

Receptors

5-HT1A receptor Show summary » More detailed page

5-HT1B receptor Show summary » More detailed page

5-HT1D receptor Show summary » More detailed page

5-ht1e receptor Show summary » More detailed page

5-HT1F receptor Show summary » More detailed page

5-HT2A receptor Show summary » More detailed page

5-HT2B receptor Show summary » More detailed page

5-HT2C receptor Show summary » More detailed page

5-HT4 receptor Show summary » More detailed page

5-ht5a receptor Show summary » More detailed page

5-ht5b receptor Show summary » More detailed page

5-HT6 receptor Show summary » More detailed page

5-HT7 receptor Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

5-Hydroxytryptamine receptors. Accessed on 03/09/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.