5-Hydroxytryptamine receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [63] and subsequently revised [57]) are, with the exception of the ionotropic 5-HT3 class, GPCR receptors where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [13,156]. Most 5-HT receptors (except 5-ht 1e and 5-ht 5a/5b) play specific roles mediating functional responses in different tissues (reviewed by [121,147].

Receptors

5-HT1A receptor Show summary » More detailed page

5-HT1B receptor Show summary » More detailed page

5-HT1D receptor Show summary » More detailed page

5-ht1e receptor Show summary » More detailed page

5-HT1F receptor Show summary » More detailed page

5-HT2A receptor Show summary » More detailed page

5-HT2B receptor Show summary » More detailed page

5-HT2C receptor Show summary » More detailed page

5-HT4 receptor Show summary » More detailed page

5-ht5a receptor Show summary » More detailed page

5-ht5b receptor Show summary » More detailed page

5-HT6 receptor Show summary » More detailed page

5-HT7 receptor Show summary » More detailed page

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Daniel Hoyer, Rodrigo Andrade, Nicholas M. Barnes, Gordon Baxter, Joel Bockaert, Theresa Branchek, Marlene L. Cohen, Aline Dumuis, Richard M. Eglen, Manfred Göthert, Mark Hamblin, Michel Hamon, Paul R. Hartig, René Hen, Katharine Herrick-Davis, Rebecca Hills, Patrick P. A. Humphrey, Klaus Peter Latté, Luc Maroteaux, Graeme R. Martin, Derek N. Middlemiss, Ewan Mylecharane, Stephen J. Peroutka, Pramod R. Saxena, Andrew Sleight, Carlos M. Villalon, Frank Yocca. 5-Hydroxytryptamine receptors. Accessed on 29/08/2015. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol. 170: 1459–1581.