Ligand id: 2290

Name: ondansetron

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 39.82
Molecular weight 293.15
XLogP 2.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of nausea and vomiting associated with chemotherapy, radiation therapy, following surgery.
Mechanism Of Action and Pharmacodynamic Effects
Selective antagonism of 5HT3 receptors expressed centrally and peripherally leads to the antiemetic activity of the drug through inhibition of the visceral afferent stimulation of the vomiting centre.
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