Ligand id: 2298

Name: diltiazem

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: diltiazem

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 84.38
Molecular weight 414.16
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina, either alone or in combination with an ACE inhibitor.
Mechanism Of Action and Pharmacodynamic Effects
Diltiazem appears to block voltage-dependent L-type calcium channels, but the exact machanism remains unclear. However, the drug-induced effect is a decrease in intracellular calcium in myocardial and vascular smooth muscle cells which causes inhibition of contraction in myocardial smooth muscle cells, and dilation of the coronary and systemic arteries. The net result is improved blood flow and oxygen delivery to myocardial tissues and improved function.