bepridil

Ligand id: 2337

Name: bepridil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 10
Topological polar surface area 15.71
Molecular weight 366.27
XLogP 6.8
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Was used to treat hypertension and angina as it induces vasodilation, especially of the coronary vasculature. However, use of this drug was discontinued in the US due to it causing ventricular arrhythmias.
A recent report of in vitro investigations suggests that bepridil may provide a multifactorial therapeutic modality for Alzheimer's disease by different mechanisms of action [1].
Mechanism Of Action and Pharmacodynamic Effects
Bepridil inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle cells by acting as an antagonist of calmodulin. However, we have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.