Ligand id: 2404

Name: nortriptyline

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View more information in the IUPHAR Pharmacology Education Project: nortriptyline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 12.03
Molecular weight 263.17
XLogP 8.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Primarily indicated for the treatment of major depressive disorder, but is also used in the treatment of chronic pain, irritable bowel syndrome, sleep disorders, diabetic neuropathy, agitation and insomnia, and for the prevention of migraine.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of nortriptyline is unknown. It exhibits activity as a serotonin and/or noradrenaline reuptake inhibitor at the neuronal membrane, and also has activity across several GPCR families, including α-adrenoceptors, serotonin 5-HT2 receptors, muscarinic acetylcholine receptors and the histamine H1 receptor, and it also blocks sodium channels.
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