verapamil

Ligand id: 2406

Name: verapamil

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: verapamil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 13
Topological polar surface area 63.95
Molecular weight 454.28
XLogP 4.71
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used therapeutically as a calcium channel blocker in the treatment of cardiac arrhythmia, hypertension and angina.
Mechanism Of Action and Pharmacodynamic Effects
A class IV antiarrhythmic agent, verapamil decreases impulse conduction through the AV node.
External links