diazoxide

Ligand id: 2409

Name: diazoxide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 66.91
Molecular weight 229.99
XLogP 1.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Diazoxide acts as a peripheral vasodilator and is used to reduce blood pressure.
Mechanism Of Action and Pharmacodynamic Effects
Diazoxide activates potassium channels which in turn switches off voltage-gated calcium ion channels, This inhibits calcium flux across the sarcolemma leading to failure of the contractile response and hence causes local smooth muscle relaxation.