pinacidil

Ligand id: 2412

Name: pinacidil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 73.1
Molecular weight 245.16
XLogP 2.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Pinacidil is an anti-hypertension drug, to be used in combination with diuretics. This drug was originally approved by the US FDA in 1989, but use has since been discontinued. The drug may still be approved for use in other countries.
Mechanism Of Action and Pharmacodynamic Effects
Pinacidil acts to open ATP-sensitive potassium channels [1] on smooth muscle cells causing peripheral vasodilatation of arterioles, and thereby reduces blood pressure. However, we have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.