pinacidil

Ligand id: 2412

Name: pinacidil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 73.1
Molecular weight 245.16
XLogP 2.81
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H. (1995)
Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells.
J. Pharmacol. Exp. Ther.275 (2): 681-92. [PMID:7473155]
2. Inagaki N, Gonoi T, Clement JP, Wang CZ, Aguilar-Bryan L, Bryan J, Seino S. (1996)
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels.
Neuron16 (5): 1011-7. [PMID:8630239]
3. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y. (1996)
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
J. Biol. Chem.271 (40): 24321-4. [PMID:8798681]
4. Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y. (1997)
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
J. Physiol. (Lond.)499 ( Pt 3): 715-20. [PMID:9130167]