Ligand id: 2421

Name: amiloride

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 159.29
Molecular weight 229.05
XLogP -1.18
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of congestive heart failure or hypertension as an adjunctive treatment to thiazide diuretics or other kaliuretic-diuretic agents.
Amiloride, along with riluzole and fluoxetine are repurposing candidates as potential therapeutics for secondary progressive multiple sclerosis (SPMS or late MS), having already been shown to provide neuroprotective benefit [1,3,5-6]. A Phase II clinical trial (NCT01910259, MS-SMART trial) is recruiting patients (April 2015).
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