flecainide

Ligand id: 2560

Name: flecainide

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 59.59
Molecular weight 414.14
XLogP 4.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Flecainide is an anti-arrhythmic drug used to control ventricular and atrial arrhythmias and tachycardias.
Mechanism Of Action and Pharmacodynamic Effects
Flecainide acts to block sodium channels. The drug's antiarrhythmic action is mediated through sodium channels in Purkinje fibers, where it blocks the calcium ion fluxes required for the initiation and conduction of nerve impulses. However, we have been unable to find affinity data for this drug (at the human target) to substantiate this MMOA.