Ligand id: 2603

Name: astemizole

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 42.32
Molecular weight 458.25
XLogP 6.61
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Astemizole is a long-acting, non-sedating antihistamine used to prevent sneezing, rhinitis and conjunctivitis, and other symptoms of various allergic inflammatory conditions.
Mechanism Of Action and Pharmacodynamic Effects
Astemizole suppresses the formation of edema, flare, and pruritus resulting from histaminic activity by acting as a reversible histamine H1-receptor antagonist.