Ligand id: 2807

Name: bexarotene

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 348.21
XLogP 10.78
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Bexarotene is an antineoplastic agent used in the treatment of cutaneous T cell lymphoma, usually following failure of previous treatments. Bexarotene shows activity in all clinical stages of cutaneous T cell lymphoma and has been used for non-indicated cancers such as lung and breast cancer, and Kaposi’s sarcoma.
Mechanism Of Action and Pharmacodynamic Effects
The mechanism of action is poorly understood but involves selective activation of retinoid X receptors (RXRα, RXRβ and RXRγ)