drospirenone

Ligand id: 2874

Name: drospirenone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 43.37
Molecular weight 366.22
XLogP 4.35
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Drospirenone is used in combination with estrogens (such as ethinylestradiol or estradiol) in many female contraceptive and hormone replacement therapy medications. Drospirenone may also be used to treat acne and severe forms of premenstrual syndrome. Drospirenone does not have marketing approval as a single compound, it is only approved in combination with other hormones.
Mechanism Of Action and Pharmacodynamic Effects
Binding of drospirenone to the progesterone receptor reduces the frequency of gonadotropin releasing hormone (GnRH) pulses from the hypothalamus and blunts the pre-ovulatory LH surge, thereby reducing the likelihood of effective ovulation.