Ligand id: 3141

Name: alendronate

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 6
Rotatable bonds 5
Topological polar surface area 180.93
Molecular weight 249.02
XLogP -4.3
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
One of the nitrogenous bisphosphonate group of drugs used in the treatment of bone diseases including osteoporosis and Paget's disease.
Mechanism Of Action and Pharmacodynamic Effects
Nitrogenous bisphosphonates act on bone metabolism by binding and blocking the enzyme farnesyl diphosphate synthase (FPPS) in the HMG-CoA reductase (mevalonate) pathway. Downstream events cause apoptosis of osteoclasts, the cells responsible for bone resorption. This action leads to reduced breakdown of bone. As this type of drug binds to bone surfaces, their action is targeted to bone.