zoledronic acid

Ligand id: 3177

Name: zoledronic acid

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 5
Rotatable bonds 4
Topological polar surface area 172.73
Molecular weight 272
XLogP -4.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A bisphosphonate used to prevent skeletal fractures in cancer patients and in the treatment of osteoporosis
Mechanism Of Action and Pharmacodynamic Effects
Zoledronic acid acts by inhibiting osteoclast activity and reduces bone reabsorption and turnover. This is due to its affinity for the bone mineral matrix component, hydroxyapatite, and its inhibition of enzyme farnesyl diphosphate synthase (FPP synthase, FDPS). FPP synthase inhibition prevents synthesis of the isoprenoid lipids, farnesyl diphosphate and geranylgeranyl diphosphate, which are involved in post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins.
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