Ligand id: 321

Name: darifenacin

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: darifenacin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.56
Molecular weight 426.23
XLogP 7.59
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of urinary incontinence.
Mechanism Of Action and Pharmacodynamic Effects
Darifenacin is an antagonist selective for the M3 muscarinic acetylcholine receptor. Antagonism of this receptor leads to relaxation of urinary bladder smooth muscle and reduces the urgency to urinate.