diazepam

Ligand id: 3364

Name: diazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 32.67
Molecular weight 284.07
XLogP 3.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
There are many indications for the use of diazepam, including treatment of severe anxiety disorders, management of insomnia, as a sedative, as an anticonvulsant, and additionally in the management of alcohol withdrawal syndrome.
Mechanism Of Action and Pharmacodynamic Effects
Diazepam is a positive allosteric modulator of the GABA-A receptor; anion channel, enhancing γ-aminobutyric acid activity.