diazepam

Ligand id: 3364

Name: diazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 32.67
Molecular weight 284.07
XLogP 3.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Drummond AH, Hughes PJ, Ruiz-Larrea F, Joels LA. (1989)
Use of receptor antagonist in elucidating the mechanism of action of TRH in GH3 cells.
Ann. N. Y. Acad. Sci.553: 197-204. [PMID:2566295]
2. Flockhart DA. 
Drug Interactions: Cytochrome P450 Drug Interaction Table. Indiana University School of Medicine (2007).
Accessed on 18/11/2014. Modified on 18/11/2014. http://medicine.iupui.edu/clinpharm/ddis/clinical-table/
3. Krishek BJ, Moss SJ, Smart TG. (1998)
Interaction of H+ and Zn2+ on recombinant and native rat neuronal GABAA receptors.
J. Physiol. (Lond.)507 ( Pt 3): 639-52. [PMID:9508826]
4. Pritchett DB, L├╝ddens H, Seeburg PH. (1989)
Type I and type II GABAA-benzodiazepine receptors produced in transfected cells.
Science245 (4924): 1389-92. [PMID:2551039]
5. Waugh DJ, Gaivin RJ, Damron DS, Murray PA, Perez DM. (1999)
Binding, partial agonism, and potentiation of alpha(1)-adrenergic receptor function by benzodiazepines: A potential site of allosteric modulation.
Journal of Pharmacology & Experimental Therapeutics291: 1164-1171. [PMID:10565838]