tolterodine

Ligand id: 360

Name: tolterodine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 23.47
Molecular weight 325.24
XLogP 7.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of urinary incontinence.
Mechanism Of Action and Pharmacodynamic Effects
Tolterodine and its active metabolite 5-hydroxymethyltolterodine are competiitve antagonists at muscarinic receptors . This results in an inhibition of bladder contraction, decrease in detrusor pressure and an incomplete emptying of the bladder.
External links