Ligand id: 360

Name: tolterodine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 23.47
Molecular weight 325.24
XLogP 7.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Gillberg PG, Sundquist S, Nilvebrant L. (1998)
Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists.
Eur. J. Pharmacol., 349 (2-3): 285-92. [PMID:9671109]
2. Nelson CP, Nahorski SR, Challiss RA. (2006)
Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor.
J Pharmacol Exp Ther, 316: 279-288. [PMID:16188951]
3. Sinha S, Gupta S, Malhotra S, Krishna NS, Meru AV, Babu V, Bansal V, Garg M, Kumar N, Chugh A et al.. (2010)
AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder.
Br. J. Pharmacol., 160 (5): 1119-27. [PMID:20590605]