Ligand id: 3634

Name: pranlukast

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 119.09
Molecular weight 481.18
XLogP 7.62
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used as an adjunct to the standard therapy of inhaled steroids with inhaled beta-agonists. There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency websites. Individual national approval agencies may have granted marketing authorisation.
Mechanism Of Action and Pharmacodynamic Effects
Inhibits the binding of leukotriene D4 at the CysLT receptor, preventing airway edema, smooth muscle contraction and enhanced secretion of thick viscous mucus.