clozapine

Ligand id: 38

Name: clozapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 30.87
Molecular weight 326.13
XLogP 4.32
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic agent used in the treatment of treatment resistant schizophrenia. This drug may also be used to reduce suicide risk in psychotic patients (US) and for the treatment of psychosis in Parkinson's disease (Europe)
Mechanism Of Action and Pharmacodynamic Effects
Clozapine is a selective monoaminergic antagonist, whose actions arise predominantly through high affinity interactions with serotonin 5HT2 receptors, dopamine D2 receptors, α1- and α2-adrenoceptors, and histamine H1 receptors. Antagonistic effects at D2 receptors in the mesolimbic pathway and 5-HT2A receptors in the frontal cortex likely contribute to the antipsychotic action of clozapine in schizophrenia patients.