Ligand id: 3990

Name: mecamylamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 167.17
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of severe essential hypertension and in uncomplicated cases of malignant hypertension.
Mechanism Of Action and Pharmacodynamic Effects
Blocker of the neuronal acetylcholine receptor on ganglions , which prevents stimulation of the postsynaptic receptors by acetylcholine. This leads to a reduction in sympathetic tone, vasodilation, and reduced cardiac output.
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