camicinal

Ligand id: 4035

Name: camicinal

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 47.61
Molecular weight 424.26
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Camicinal is being assessed in Phase II clinical trial as a treatment for delayed gastric emptying (gastroparesis). Click here to link to ClinicalTrials.gov's full list of Phase II camicinal trials.
Mechanism Of Action and Pharmacodynamic Effects
Gastroparesis can occur when the vagus nerve (which controls stomach contractions) or muscles of the stomach and intestines fail to function normally. This slows or stops gastro-intestinal transit in the digestive tract. Gastroparesis can be the result of autonomic neuropathy which is associated with diabetes, Parkinson's disease and other diseases, or as a result of abdominal surgery. Camicinal-induced activation of the motilin receptor stimulates contraction of gut smoooth muscle, to improve gut motility [1-2].