Ligand id: 4233

Name: ketamine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 29.1
Molecular weight 237.09
XLogP 2.97
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the induction and maintenance of anaesthesia in both human and veterinary medicine. Rapidly acting ionotropic glutamate channel blocker.
Mechanism Of Action and Pharmacodynamic Effects
Ketamine is an allosteric modulator of the NMDA receptor, and also interacts with opioid, monoaminergic and muscarinic receptors and voltage sensitive Ca ion channels.