Ligand id: 4252

Name: mefloquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 45.15
Molecular weight 378.12
XLogP 5.17
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of malarial infections.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of mefloquine is unknown but it believed to result from the formation of toxic complexes with free heme that damage membranes and interact with other plasmodial components.
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