mefloquine

Ligand id: 4252

Name: mefloquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 45.15
Molecular weight 378.12
XLogP 5.17
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Mefloquine should not be prescribed to prevent malaria in patients with major psychiatric disorders or with a history of seizures. In 2013, the FDA added a 'Boxed Warning' to highlight the risks of neurological side effects that may persist or become permanent.
Mechanism Of Action and Pharmacodynamic Effects
The exact mechanism of action of mefloquine is unknown but it believed to result from the formation of toxic complexes with free heme that damage membranes and interact with other plasmodial components.
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