Ligand id: 4252

Name: mefloquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 45.15
Molecular weight 378.12
XLogP 5.17
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Mefloquine is active against the erythrocytic stages of Plasmodium species, and not against hepatic stages of the parasite. It is active against chloroquine resistant malaria parasites.
Selectivity at Human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
VRAC Channel blocker - - - -
Ligand mentioned in the following text fields