Ligand id: 4252

Name: mefloquine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 45.15
Molecular weight 378.12
XLogP 5.17
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Mefloquine is active against the erythrocytic stages of Plasmodium species, and not against hepatic stages of the parasite. It is active against chloroquine resistant malaria parasites.
Selectivity at ion channels
Key to terms and symbols Click on species/strain names for details Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
VRAC Hs Channel blocker - - - -
Ligand mentioned in the following text fields