naratriptan

Ligand id: 45

Name: naratriptan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 73.58
Molecular weight 335.17
XLogP 1.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of migraine.
Mechanism Of Action and Pharmacodynamic Effects
Agonism of presynaptic 5-HT1D receptors by naratriptan inhibits both dural vasodilation and inflammation. Agonism of 5-HT1B and 5-HT1D receptors in the brainstem leads to inhibition of trigeminal nuclei cell excitability while vascular 5-HT1B receptor agonism leads to vasoconstriction or meningeal, dural cerebraland pial vessels. The combination of these three properties of naratriptan are belived to account for its effect as an anti-migraine drug.
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