Ligand id: 4790

Name: paroxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 39.72
Molecular weight 329.14
XLogP 4.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment if major depressive disorder, obsessive compulsive disorder (OCD), panic disorder, social anxiety disorder, generalised anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and pre-menstrual dysphoric disorder (PMDD).
Mechanism Of Action and Pharmacodynamic Effects
Paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake by SLC6A4 (serotonin transporter, or SERT). The drug competes for serotonin binding within the central ligand binding site of the transporter [1].
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