Ligand id: 4799

Name: cladribine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 119.31
Molecular weight 285.06
XLogP -0.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Cladribine is used to treat lymphoproliferative diseases such as hairy-cell leukemia, and also multiple sclerosis
Mechanism Of Action and Pharmacodynamic Effects
Incorporation of phosphorylated cladribine is believed to cause DNA strand breakage and inhibition of DNA synthesis and repair in conjunction with additional effects on ATP depletion. The net effect is cell death, potentially as a result of cells accumulating in G1/S phase and being unable to enter S phase. Due to the complex and varied nature of nucleic acids we do not include DNA or RNA as targets on this database.