Ligand id: 4821

Name: vigabatrin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 63.32
Molecular weight 129.08
XLogP 0.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of epilepsy as an adjunctive therapy in treatment-resistant cases for refractory complex partial seizures, and secondary generalized seizures. Also used alone for infantile spasms in West syndrome.
Mechanism Of Action and Pharmacodynamic Effects
Increases concentrations of GABA in the brain by irreversibly inhibiting the enzymes that catabolize it.
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