aciclovir

Ligand id: 4829

Name: aciclovir

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 114.43
Molecular weight 226.09
XLogP -1.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Aciclovir is a commonly used antiviral drug, used for the treatment of herpes simplex virus infections, as well as in the treatment of varicella zoster (chickenpox) and herpes zoster (shingles).
Mechanism Of Action and Pharmacodynamic Effects
Aciclovir is a guanosine analogue and is converted by host cell kinases to aciclovir triphosphate (ACV-TP), which then competitively inhibits and inactivates viral DNA polymerases [2] and is incorporated into viral DNA [1,3]. This action halts viral replication.